M2e-based universal influenza vaccines: a historical overview and new approaches to development
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چکیده
منابع مشابه
M2e-Based Universal Influenza A Vaccines
The successful isolation of a human influenza virus in 1933 was soon followed by the first attempts to develop an influenza vaccine. Nowadays, vaccination is still the most effective method to prevent human influenza disease. However, licensed influenza vaccines offer protection against antigenically matching viruses, and the composition of these vaccines needs to be updated nearly every year. ...
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Influenza virus causes acute upper and lower respiratory infections and is the most likely, among known pathogens, to cause a large epidemic in humans. Influenza virus mutates rapidly, enabling it to evade natural and vaccine-induced immunity. Furthermore, influenza viruses can cross from animals to humans, generating novel, potentially pandemic strains. Currently available influenza vaccines i...
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Vaccination is the most cost-effective way to reduce the considerable disease burden of seasonal influenza. Although seasonal influenza vaccines are effective, their performance in the elderly and immunocompromised individuals would benefit from improvement. Major problems related to the development and production of pandemic influenza vaccines are response time and production capacity as well ...
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The development of vaccines has been one of the most important contributions of immunology to public health to date. Although several infectious diseases have all but vanished thanks to effective vaccines, the most common infectious disease, influenza, still represents a major threat to public health. This is more concerning than ever before in light of potentially virulent avian pandemic strai...
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Influenza virus is one of the most important respiratory pathogens with significant medical and economic burdens [1-3]. It belongs to genera A, B and C of the family Orthomyxoviridae with type A viruses being the primary pathogens claimed for seasonal and pandemic influenza outbreaks [4]. Type A viruses can be further divided into different subtypes based on the serotypes of their main surface ...
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ژورنال
عنوان ژورنال: Journal of Biomedical Science
سال: 2019
ISSN: 1423-0127
DOI: 10.1186/s12929-019-0572-3